While combining melatonin and tylenol may enhance pain relief, it's essential to be mindful of their individual side effects and drug interactions. Both melatonin and tylenol can cause drowsiness, so combining them may intensify this effect. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another. If you are being treated with any of the following medications, you should not use melatonin without first discussing it with your health care provider.
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